Recent results have demonstrated the ability of the CryoARM/K3 combination to produce structures at ultra-high resolution for particles of various sizes and symmetries. Following the initial technical achievements, this hardware combination is now being used to provide important biological insights as well. In this presentation, Alan Merk, Electron Microscopist from NIH, will review some of the structures we have obtained in the past with the CryoARM/K3 using SerialEM, report on ongoing work with Latitude S, and look forward to future directions.