Elsa Cryo-Transfer Holder Series

The Elsa™ cryo-transfer holder series is a next-generation, single-tilt liquid nitrogen holder designed for the frost-free transfer of a sample at liquid nitrogen temperature into a transmission electron microscope (TEM). These holders are primarily used for imaging radiation-sensitive, frozen-hydrated specimens for single particle cryo-electron microscopy (cryo-EM) and beam-sensitive applications such as battery materials.

• Larger dewar, redesigned from the ground up: Increases the liquid nitrogen volume by 2.5x
• New multi-specimen tip: Load three TEM grids at once to significantly accelerate system throughput
• Extended hold time: Allows >8 h of stable, high-resolution imaging
• <1.5 nm/min drift rate: Ensures that image quality is high during data collection
• Resolve <2.3 Å features: Enables high-resolution imaging even under cryo-conditions
• Centrosymmetric design: Reduces settling and drift during tomography by maintaining the center of gravity during a stage tilt

This holder comes with three different tip configurations. The multi-specimen tip allows three grids to be loaded at once. The ultra-low-profile single specimen tip uses the Quickload™ clipping-free mechanism to secure the specimen and provides the highest tilt range of any side-entry cryo-transfer holder available today (±80° tilt). Finally, the standard tip, often considered the easiest for novice users, uses a clipping mechanism to secure the sample.