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Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

ScienceAdvances
2021

Xu, C.; Wang, Y.; Liu, C.; Zhang, C.; Han, W.; Hong, X.; Wang, Y.; Hong, Q.; Wang, S.; Zhao, Q.; Wang, Y.; Yang, Y.; Chen, K.; Zheng, W.; Kong, L.; Wang, F.; Zuo, Q.; Huang, Z.; Cong, Y.

They spent 12 years solving a puzzle. It yielded the first COVID-19 vaccines.

National Geographic
2020

Kramer, J.

Spatial mapping of electrostatics and dynamics across 2D heterostructures

Condensed Matter
2020

Murthy, A. A.; Stanev, T. K.; Ribet, S. M.; Liu, P.; Watanabe, K.; Taniguchi, T.; Stern, N. P.; dos Reis, R.; Dravid, V. P.

Coronavirus infection induces progressive restructuring of the endoplasmic reticulum involving the formation and degradation of double membrane vesicles

Virology
2020

Mihelc. E. M.; Baker, S. C.; Lanman, J. K.

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA

Molecular Cell
2020

Yuan, S.; Peng, L.; Park, J. J.; Hu, Y.; Devarkar, S. C.; Dong, M. B.; Shen, Q.; Wu, S.; Chen, S.; Lomakin, I. B.; Xiong, Y.

Cryo-EM structures of SARS-CoV-2 spike without and with ACE2 reveal a pH-dependent switch to mediate endosomal positioning of receptor-binding domains

Cell Host & Microbe
2020

Zhou, T.; Tsybovsky, Y.; Gorman, J.; Rapp, M.; Cerutti, G.; Chuang, G. -Y.; Katsamba, P. S.; Sampson, J. M.; Schön, A.; Bimela, J.; Boyington, J. C.; Nazzari, A.; Olia, A. S.; Shi, W.; Sastry, M.; Stephens, T.; Stuckey, J.; Teng, I. -T.; Kwong, P. D

Electronically coupled 2D polymer/MoS2 heterostructures

Journal of American Chemical Society
2020

Balch, H. B., Evans, A. M., Dasari, R. R., Li, H., Li, R., Thomas, S., Wang, Q., Bisbey, R. P., Slicker, K., Castano, I., Xun, S., Jiang, L., Zhu, C., Gianneschi, N., Ralph, D. C., Brédas, J-L., Marder, S. R., Dichtel, W. R., Wang, F.

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

Science
2020

Linsky, T. W.; Vergara, R.; Codina, N.; Nelson, J. W.; Walker, M. J.; Su, W.; Barnes, C. O.; Hsiang, T. -Y.; Esser-Nobis, K.; Yu, K.; Reneer, B.; Hou, Y. J.; Priya, T.; Mitsumoto, M.; Pong, A.; Lau, Y.; Mason, M. L.; Chen, J.; Chen, A.; Berrocal, T.; Peng, H.; Clairmont, N. S.; Castellanos, J.; Lin, Y. -R..; Josephson-Day, A.; Baric, R. S.; Fuller, D. H.; Walkey, C. D.; Ross, T. M.; Swanson, R.; Bjorkman, P. J.; Gale Jr., M.; Blancas-Mejia, L. M.; Yen, H. -L.; Silva, D. -A.

Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection

Cell Research
2020

Yao, H.; Sun, Y.; Deng, Y. -Q.; Wang, N.; Tan, Y.; Zhang, N. -N.; Li, X. -F.; Kong, C.; Xu, Y. -P.; Chen, Q.; Cao, T. -S.; Zhao, H.; Yan, X.; Cao, L.; Lv, Z.; Zhu, D.; Feng, R.; Wu, N.; Zhang, W.; Hu, Y.; Chen, K.; Zhang, R. -R.; Lv, Q.; Sun, S.; Zhou, Y.; Yan, R.; Yang, G.; Sun, X.; Liu, C.; Lu, X.; Cheng, L.; Qiu, H.; Huang, X. -Y.; Weng, T.; Shi, D.; Jiang, W.; Shao, J.; Wang, L.; Zhang, J.; Jiang, T.; Lang, G.; Qin, C. -F.; Li, L.; Wang, X.

Structure-based development of human antibody cocktails against SARS-CoV-2

Cell Research
2020

Wang, N.; Sun, Y.; Feng, R.; Wang, Y.; Guo, Y.; Zhang, L.; Deng, Y. -Q.; Wang, L.; Cui, Z.; Cao, L.; Zhang, Y. -J.; Li, W.; Zhu, F. -C.; Qin, C. -F.; Wang, X.

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